(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester is an intermediate of Rosuvastatin.
(4R-Cis)-tert-butyl 6-hydroxymethyl-2,2-dimethyl-1, 3-dioxane-4-acetate, often abbreviated as Tertbutyl 6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-carboxylate.Nature:
-Appearance: colorless liquid
-Molecular formula: C14H26O5
-Solubility: Soluble in common organic solvents such as ethers, alcohols and esters
-Melting Point/Boiling Point: No Report
-Relative density: no report
-Stability: stable, avoid contact with strong oxidants and high temperatures
Use:
- (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester is commonly used as a chiral intermediate for the synthesis of a variety of compounds and drugs.
-It can be used as a protecting group in organic synthesis to provide protection for hydroxyl groups.
-It can also be used for asymmetric catalytic reactions in drug synthesis and synthesis of chiral drugs.
Preparation Method:
The specific preparation method can integrate multi-step reactions. One common preparation is by reacting 1,4-cyclohexanediol with tert-butyryl chloride to give a tert-butyrate compound, which is then converted to (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester by photochemical hydroxymethylation.
Safety Information:
- (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester specific safety information may vary from manufacturer to supplier, please refer to the relevant safety technical instructions and instructions when using.
-Wear appropriate personal protective equipment such as chemical goggles, protective gloves and protective clothing when used.
-Avoid contact with skin, eyes and respiratory tract. In case of contact or aspiration, rinse immediately with water and seek medical advice.
-During use and storage, please follow the correct operation and storage requirements of chemicals, avoid mixed storage with other chemicals, and keep away from fire and heat sources.
