3-bromo-2-methoxyaniline is an intermediate wildly used in organic synthesis. In the synthesis of Eltrombopag olamine, 3-bromo-2-methoxyaniline is used as a starting material.
Nature:3-Bromo-2-methoxyaniline is a white crystalline solid with special chemical properties. It has a density of 1.527g/cm3 and a melting point of 75-76°C. It is stable at room temperature, soluble in ethanol, chloroform and dichloromethane, but insoluble in water.
Use:3-Bromo-2-methoxyaniline, as an important organic synthesis intermediate, is widely used in the preparation of other compounds. It can be used in the manufacture of pesticides, pharmaceuticals, dyes and organic synthetic compounds.
Method:
The preparation method of 3-bromo-2-methoxyaniline can be obtained by the reaction of aniline and methyl bromide. Specific steps are as follows:
1. Dissolve aniline and alkali (such as sodium carbonate) in hydrochloric acid.
2. Add excess methyl bromide and react for a period of time by stirring.
3. The product was isolated and extracted, and purified by crystallization to obtain 3-bromo-2-methoxyaniline.
Safety Information:
3-bromo -2-methoxy aniline in the use of the process need to pay attention to some safety matters:
-It is an organic substance that may be irritating to the skin, eyes and respiratory system, so it is necessary to wear protective gloves, goggles and masks during operation.
-Avoid prolonged exposure to its vapor or dust, and ensure that it is used in a well-ventilated place.
-During use or storage, keep away from fire and high temperature.
-In case of contact with skin or eyes, rinse immediately with plenty of water and consult a doctor.
In general, the proper use and storage of 3-bromo-2-methoxyaniline is important to ensure work safety and health.
