2,4-diamino-6-(hydroxymethyl)-pteridine is used as intermediate of Methotrexate.
Preparation: A method for preparing 2,4 diamino 6 bromomethyl pteridine with 1,3 dihydroxyacetone and 2,4,5,6 Four amino pyrimidine hydrochloride in acidic molecular sieve catalyzed cyclization directly in one step to obtain high purity 2,4 diamino 6 hydroxymethyl pteridine. After the reaction is completed, the product can be obtained by direct filtration, and the operation process is simple and the cost is low. The technical scheme is the preparation of an improved 2,4 diamino 6 bromomethyl pteridine, the reaction takes 2,4,5,6 Four amino pyrimidine hydrochloride as raw material, acidic 4A molecular sieve as a catalyst, in the presence of oxygen and 1,3 dihydroxyacetone reaction to produce 2,4 diamino 6 hydroxymethyl pteridine, and then in the NBS and triphenylphosphine bromine under the action of product 2,4 diamino 6 bromomethyl pteridine.
