(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate is an intermediate of synthesis of Ticagrelor.
Overview: (1R,2S)-2-(3, 4-difluorophenyl) cyclopropylamine (R)-mandelate is a light yellow to white powder and can be used as a pharmaceutical intermediate.
Use: (1R,2S)-2-(3, 4-difluorophenyl) cyclopropylamine (R)-mandelate is an intermediate for preparing orally active reversible P2Y12 receptor antagonists (such as Ticagrelor(T437700)) to prevent thrombosis.
Application: (1R,2S)-2-(3, 4-difluorophenyl) cyclopropylamine (R)-mandelate is a carboxylic acid derivative, which can be used as an intermediate of the anticoagulant drug ticagrelor.
Preparation: Stereoselective synthesis of (1R,2R)-2-(3, 4-difluorophenyl) cyclopropylnitrile II through the cyclopropanylation reaction of camphor matium ylide I and acrylonitrile, and then through hydrolysis and holfman degradation reaction to obtain the target product, (1R,2S)-2-(3, 4-Difluorophenyl) cyclopropylamine (R)-mandelate.
