(1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as intermediate in synthesis of Apixaban, mainly used in laboratory research and industrial production process.
Appearance: colorless crystal or white solid Molecular formula: C15H16N2O2 Molecular weight: 252.30g/molThe compound is commonly used in pharmaceutical and chemical research and has the following uses:
1. Pharmaceutical field: It can be used as an intermediate of anticancer drugs or antibacterial drugs in drug research and development.
2. Chemical research field: It can be used in organic synthesis reactions, such as coupling reactions and aromatic nuclear olefin synthesis.
Regarding the preparation of this compound, a common method is to synthesize it through the following synthetic route:
First, 4-aminobenzoic acid is reacted with acetone under an alkaline condition by a nucleophilic substitution reaction to produce a 1-(4-aminophenyl)-5,6-dihydro -2(1H)-pyridone compound.
Then, this compound is subjected to a condensation reaction with morpholine in the presence of sodium hydride to give the target compound 1-(4-AMoInophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone.
Regarding safety information, specific toxicity and safety data for 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone may depend on the specific use and composition of the mixture. However, it is generally recommended to take appropriate laboratory operations and personal protective measures when using the compound, such as wearing laboratory gloves, eye and respiratory protection equipment, and operating under protective facilities. Comply with regulations and safe operating procedures when using or handling the compound.
